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Post-Doc Position

Post-Doc Position

Unraveling the Mechanosensitivity of Actin Bundles

A 2-year postdoctoral position is now opened. To apply, please contact Antoine Jégou

Eukaryotic cells constantly integrate external biochemical and mechanical signals to timely accomplish key cellular functions. To perform its numerous tasks, the actin cytoskeleton is organized in modules where filaments assemble following specific architectures. One of these key elementary modules is the filament bundle : unbranched parallel filaments crosslinked together by bundling proteins, that can sense and generate forces.

Formin are fascinating proteins, that processively track barbed-ends and enhance filament polymerization. In filopodia, bundling of the filaments is achieved by fascins. To date nothing is known on how actin polymerization in bundles is controlled or even if mechanics can affect its dynamics. This is central to understand how filopodia for example can be sensory organelles.

The ‘Regulation of Actin Assembly Dynamics’ team has developed a novel single actin filament microfluidics approach that will serve as a powerful starting point. This project will tackle the mechanosensitivity of actin bundles by studying them for the first time concomitantly at the single filament and meso-scale actin bundles level in vitro.


Measuring formin processivity using microfluidics

(A) 3 inlets microfluidics chambers allow rapid change of biochemical conditions and parallel monitoring of hundreds of actin filaments. (B) Formins specifically anchored to the glass surface can be submitted to tension via viscous drag force along the actin filament (Jegou et al, Nat Comm., 2013).

We are seeking a highly motivated scientist with prior experience in cell biology or biophysics/biochemistry. Experience in quantitative fluorescence microscopy, image analysis and/or microfluidics is a plus. The candidate should be very creative and ready to work in an interdisciplinary team.

The position is for 2 years and subject to renewal.

To apply, please send a CV, a publication list and contact information of at least two references to Antoine Jégou (